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Abbreviations BPH: Benign prostatic hyperplasia LUTSs: Lower urinary tract symptoms OS: Oxidative stress DEGs: Differentially expressed genes MXRA5: Matrix-remodeling associated 5 CXCL13: C-X-C Motif Chemokine Ligand 13 BMP5: Bone morphogenetic protein 5 NELL2: Neural epidermal growth factor-like like 2 GPX3: Glutathione peroxidase 3 GSH: Glutathione ROS: Reactive oxygen species Cyto-C: Cytochrome c MMP: Mitochondrial membrane potential PCD: Programmed cell death MDA: Malondialdehyde H&E: Hematoxylin and eosin staining IHC: Immunohistochemical DMSO: Dimethyl sulfoxide T: Testosterone propionate RSL3: RAS-selective lethal 3 GPX4: Glutathione peroxidase 4 TRO: Troglitazone PPAR: Peroxisome proliferator-activated receptor Rapa: Rapamycin CQ: Chloroquine Nrf2: Nuclear factor erythroid 2-related factor 2 SOD2: Superoxide dismutase 2

Hyaluronic Acid Found throughout connective, epithelial (skin) and neural tissues, hyaluronic acid contributes to cell proliferation, differentiation and mitigation

Synergistic action of the nephrotoxic mycotoxins ochratoxin a and citrinin at nanomolar concentrations in human proximal tubule-derived cells

Cardiovascular Health: L-carnitine promotes heart health by supporting efficient fat metabolism within the heart muscles, potentially improving overall cardiovascular endurance

Thyroid autoimmunity with overt or subclinical hypothyroidism has been described in individuals with GSD Ib [13, 65]