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Mechanistically, HIF-1 binds to hypoxia-response elements (HREs) within the PD-L1 promoter, enhancing its expression in both tumor cells and immunosuppressive myeloid populations such as macrophages and MDSCs, thereby reinforcing an immune-resistant TME [329]

The research by Sampson et al

Published by Cambridge University Press on behalf of The Nutrition Society Coffee and tea are the two important dietary sources of caffeine, thus can increase consciousness and work productivity (Reference van Dam, Hu and Willett1)

Cancer, 116 (2), 506-513

Since the incorporation of pAcF at inappropriate sites could impact the stability and affinity of the nanobody, we developed computational protocol to aid in selecting ncAA incorporation sites (Fig