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[DOI] [PubMed] [Google Scholar] 159.Camargo C.A., Rifas-Shiman S.L., Litonjua A.A., Rich-Edwards J.W., Weiss S.T., Gold D.R., Kleinman K., Gillman M.W

38 For instance, when a plaque obstructs 7080% of a coronary vessel, shortness of breath and chest pain (angina), especially with exertion, may occur

Based on the December 2025 filing, that puts a decision around OctoberDecember 2026

Gauge Selection: The standard gauge is 22G to 25G, balancing the need to minimize pain with the structural integrity required to penetrate deep tissue without bending

Most of these aggregate-prone proteins cause disease through toxic gain-of-function mechanisms and their pathogenicity is associated with their propensity to aggregate