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2b,c) and the carnitine synthesis inhibitor mildronate, we validated this observation in both CCNE1-driven cell lines using both olaparib and cisplatin (Fig

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Individuals with diabetes characterized by HbA1c 6.5%, or a history of surgical or device-based obesity treatment, were excluded

PMID: 37267943 Europace Fto-mediated m6A demethylation of Lox drives atrial fibrosis and promotes atrial fibrillation in a murine model of hyperthyroidism

In this context, CVD and CKD through the accumulation of TMAO, p-Cresyl-sulfate (pCS), and indoxyl-sulfate (IS) in serum may be the result of the interplay between excess dietary choline, the increased production of TMAO by the gut microbiota, and the resulting activation of inflammatory responses and fibrosis