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Metformin significantly improves IR and hyperandrogenism, and its combination with CC enhances its ovulation-inducing effect (21, 22)

The incidence of PCD ranges from 1:40,000 to 1:120,000 in different countries or regions: with 1:20,0001:70,000 in the United States (Gallant et al., 2012), 1:40,000 in Japan (Shibata et al., 2018) and 1:120,000 in Australia (Wiley et al., 1999

however, the technology exists in early form such as experiments in using the prepro-orexin transgene via gene editing restored normal function in mice models by making other neurons produce orexin after the original set have been destroyed, or replacing the missing orexinergic neurons with hypocretin stem cell transplantation, are both steps in that direction for fixing the biology effectively permanently once applied in humans

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