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discovered that the accumulation of unfolded proteins in the mitochondrial matrix resulted in transcriptional upregulation of nuclear-encoded mitochondrial stress genes, including hsp60, hsp10, mtDnaJ, and ClpP, without interfering gene expression that was related to endoplasmic reticulum (ER) stress

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Diabetes Care 34 (6), 14311437

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By conceptualizing uric acid biology as a dynamic, multi-state process, this review offers an integrated perspective on hyperuricemia-associated diseases and suggests directions for future targeted therapeutic research

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14 Regulation of FAs other than MUFAs may also prove valuable, given the report that arachidonic acid (20:4) promotes the formation of helical S multimers, and these may resist fibril formation and result in reduced neuronal damage

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Given the interconnected relationship among biological aging hallmarks, manipulating one has potential to impact others

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