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The implications of this low certainty of evidence suggest that our confidence in the effect estimates is limited, and that the true effects may differ substantially from the reported findings

Thats important

Overall, our reported findings combined with PDH representing a likely effective anti-biofilm therapy, have the potential to impact areas of medical biofilm research beyond chronic wounds

The addition of the acetyl group makes the molecule more lipophilic (fat-soluble), allowing it to interact uniquely with specialized transport proteins in the body, fundamentally changing where it can go and what it can do once it gets there

Rebouche, 2004)