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GH-RH and its analogs exert direct effects on a variety of extra-pituitary cells/tissues, promote the survival of cardiomyocytes, protect rat heart, induce normoglycemia stimulate/ migration and proliferation of mouse embryonic fibroblasts (MEFs) in vitro, accelerate healing of skin wounds in vivo 59

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This is supported by the finding that aging leads to more oxidation of the GSH and more damaged mtDNA in the mitochondria, which can be prevented by oral antioxidant administration

Immunofluorescence analysis also revealed an enrichment of Fe2 in muscle satellite cells in the muscle tissue of the oe-TXNIP group (Fig

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