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Chem Biol Int 174:183192 Paris-Palacios S, Biagianti-Risbourg S, Vernet G (2000) Biochemical and (ultra)structural hepatic perturbation of Brachydanio rerio (Teleostei, Cyprinidae) exposed to two sublethal concentrations of copper sulphate

Daily dose: 25 units per day on a 1 ml insulin syringe

The mechanism is plausible (direct delivery should theoretically accelerate results), but the evidence base is not comparable to what exists for topical application