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Zebrafish model and treatment Zebrafish larvaes were from Nanjing Hunter Biotechnology Co., Ltd (Nanjing, China) and all experiments were conformed to the care and use of laboratory animals and ethically approved by China Pharmaceutical University Animal Care and Use Committee

The most common areas of involvement are the small and large bowel, especially the terminal ileum and cecum [11]

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CB 1 Rs are widespread in the CNS and are the most prevalent G-protein coupled receptor in the mammalian brain (Herkenham et al., 1990