Abbreviations IRI: Ischemia-reperfusion injury ROS: Reactive Oxygen Species RNS: Reactive Nitrogen Species BBB: Blood-Brain Barrier HIFs: Hypoxia-Inducible Factors PHD: Prolyl Hydroxylase NRF2: Nuclear Factor Erythroid 2Related Factor 2 NF-kB: Nuclear Factor kappa-light-chain-enhancer of activated B cells MAPK: Mitogen-Activated Protein Kinase VEGF: Vascular Endothelial Growth Factor VEGF-R1: Vascular Endothelial Growth Factor Receptor 1 VEGF-R2: Vascular Endothelial Growth Factor Receptor 2 MMPs: Matrix Metalloproteinases SOD: Superoxide Dismutase CAT: Catalase GPX: Glutathione Peroxidase DNA: Deoxyribonucleic Acid NO: Nitric Oxide ATP: Adenosine Triphosphate ETC: Electron Transport Chain mPTP: Mitochondrial Permeability Transition Pore GPX4: Glutathione Peroxidase 4 NOS: Nitric Oxide Synthase ASU: Avocado Soybean Unsaponifiable MUFAs: Monounsaturated Fatty Acids PUFAs: Polyunsaturated Fatty Acids MF: Monounsaturated Fatty acid References Soares ROS, Losada DM, Jordani MC et al (2019) Ischemia/reperfusion injury revisited: an overview of the latest pharmacological strategies
Immunity (2014) 40(1):4050
a) Early localized Lyme disease (within a month) symptoms include fever, arthralgias, myalgias, headache, the presence of a single, localized skin lesion known as erythema migrans (EM) b) Early disseminated Lyme disease (less than 3 months) symptoms such as fatigue and general weakness, cutaneous signs, typical cardiac complications include atrioventricular block, tachyarrhythmias, myopericarditis and myocardial dysfunction, neurological symptoms are aseptic meningitis, radiculopathy, encephalopathy, cranial neuropathy (especially facial nerve palsy), monomeutitis multiplex, subtle cognitive difficulties, motor and sensory radiculoneuropathy
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Improved hydration increases elasticity, reduces dryness, smooths texture, and supports overall skin health, giving a soft, supple, and youthful appearance
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