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Description

In addition, cystathionine--lyase and CBS catalyze the production of hydrogen sulfide in these processes

These early safety and pharmacokinetic studies preceded Phase 2 dose-ranging work in 20042006 and the Phase 3 pivotal trials that began in 2006

Studies in the growing field of immunometabolism support a paradigm of cellular selectivity based on demand, in which generic inhibitors of ubiquitous metabolic processes selectively affect cells with the greatest metabolic demand and have few effects on other cells of the body