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Inflammatory macrophages are the major contributor to necrotic core formation, yet TREM2+ macrophages have recently been shown to have low expression of inflammatory genes and a beneficial role in atherosclerosis 97,98,99,100,101,102

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Therefore, comprehensive mechanistic studies are necessary to elucidate vitamin metabolism and its spatiotemporal modulation across various malignancies, thereby facilitating the translation of this knowledge into clinical therapies