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Boca Raton, Fla, USA: CRC Press

Similarly, CAR T cells engineered to produce proteins that shape local immunity in a beneficial manner, such as IL-12, IL-15, and IL-18 to promote a Th1 response, or a truncated IL-6 receptor to sequester local IL-6, may augment tumoricidal activity without increasing immune-mediated pathology (23, 43)