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We used Propidium Iodide (PI)/Hoechst double staining to detect cell mortality

Piperine (Enhanced Absorption): Extracted from black pepper, it increases skin absorption by over 400%, ensuring active ingredients penetrate deeply into joint tissue

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They are targeted compounds selected to support anti-fibrotic activity and local tissue healing

14,15,16,17,18 However, these advanced restorative techniques still present increased failure rates in knees with common comorbidities (larger lesion size, kissing lesions on opposing articular surfaces, and pre-existing arthritic changes)