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10.1016/j.freeradbiomed.2010.03.016 69

887 D-mannose also protects cartilage by inhibiting HIF-2 and reducing the sensitivity of chondrocytes to ferroptosis

The enzyme can no longer be saturated with GSH in the R73 and R74 mutants leading to the paradoxical situation that mutation decreases activity at low GSH but increases activity at very high GSH concentrations