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Although numerous studies have highlighted the critical role of RCD mechanisms in NAFLD/NASH and related HCC, significant challenges remain in developing effective targeted therapies and translating them into clinical applications

other antioxidants rely on glutathione for their function which means that vitamin C, alpha-lipoic acid and vitamin E all rely on the body having enough glutathione to function

Acknowledgements The authors thank all members of the laboratory for their assistance with animal care and experimental procedures

Ma Y, Rong Q

Treatment of these cells with lapatinib, statins, trigonelline, or through genetic editing to suppress GPX4 expression can induce ferroptosis and reverse their tumor-promoting functions [28, 58, 88]