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Role of superoxide anion in the generation of other reactive species Superoxide anion (O2) which is constantly being generated through endogenous processes and exogenous sources can through different pathways or chain reactions cause the formation of several other reactive species.15 It can directly produce hydroxy radical (OH) (O2 + 2e OH) or indirectly from hydrogen peroxide which results from its dismutation by SOD (H2O2 + e OH), through Fenton reaction which occurs in the presence of Fe2+ (Fig

doi: 10.1016/j.clim.2013.10.006 93 JamesJChenYHernandezCMForsterFDagnellMChengQet al

[PubMed: 14168179] 590

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Therefore, targeting distinct lipid metabolic pathways could be a strategy to enhance sorafenib efficacy