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Once cell stress reaches its critical threshold, over-activation of the JNK signaling pathway and mitochondrial dysfunction are considered as major cellular events in APAP-induced liver injury [111, 112]

The lack of reliable technical tools for accurately assessing their absolute or even relative levels

The arithmetic average roughness ( R a ) and root mean square roughness ( R q ) were determined to be 1.83 nm and 3.71 nm, respectively, both significantly below 10 nm

NOX1 expression correlates with RAS mutational status in colorectal cancer, and immunohistochemical analysis indicates overexpression in specific cancers, emphasizing its relevance as a therapeutic target in colorectal and small intestinal cancer

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