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Traditional Chinese herbal formula, Fuzi-Lizhong pill, produces antidepressant-like effects in chronic restraint stress mice through systemic pharmacology

Prolonged exposure reduces the expression of fusion proteins such as mitofusin (MFN)1, MFN2 and optic atrophy 1 (OPA1), causing mitochondrial damage, and ultimately triggers mitophagy (85)

In one comparative study, n-propyl gallate provided the most robust protection across multiple readouts of neuroprotection, outperforming gallic acid and other analogues (40)

Although the molecular mechanisms underpinning anhydrobiosis are not yet completely understood, it seems clear that desiccation tolerance depends on the synergic action of an array of many different molecules working together