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Toxicol Lett 161(2):159166

In the realm of creating targeted DDSs, there are three prominent synthetic methods for producing polymerdrug conjugates: binding therapeutic compounds to synthetic polymeric carriers, incorporating therapeutic molecules with monomers prior to the polymerization process, and embedding drugs into polymers during their formation [62]

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However, with age, stress and disease states, the production of own glutathione decreases

80 Additionally, several studies have demonstrated that ASOs can disrupt translation initiation by targeting and masking the AUG start codon of the target mRNA