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The amylin component contributes to blood sugar control through glucagon suppression and delayed gastric emptying, both of which reduce postprandial glucose spikes

Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury

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The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions

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