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Scientific Significance and Potential Implications MOTS-c represents a novel mechanism of mitochondrial-to-nuclear signaling

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10.1007/s11655-018-3054-7 281 YangY.XuY.QianS.TangT.WangK.FengJ.et al (2023)

This fraction of cells first enters a drug-tolerant persistent state (drug tolerant state) under drug stress, and in this state, they gradually acquire stable drug resistance through adaptive mutations (7, 8), which can therefore become drug tolerant cells (DTCs)