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Rheumatoid arthritis patients receiving CoQ 10 (100 mg/day) for 2 months tended to have lower TFN- plasma levels than placebo-treated patients (Abdollahzad et al., 10 therapy in doses ranging from 60 to 300 mg/day caused no significant decrease in C-reactive protein while eliciting a significant reduction in IL-6 levels (Mazidi et al., 2017)

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In contrast, GAA and the ferroptosis inhibitor liproxstatin-1 (Lip-1) significantly activated the NRF2/SLC7A11/GPX4 signaling pathway and mitigated A 25-35 -induced neuronal injury (Lu et al., 2025)