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Final mass yield was 4.1 kg (36.5%, theoretical 5.627 kg), and due to the chemical control in hydrolysis, an ee of 99.4% Overall mass yield 4.1 kg (36.5%, theoretical 5.627 kg) ee 99.4% Read more Organic Process Research and Development 2015, 19, 819830 Process improvement with Biotage Flash 400 US major Pharmaceutical Company Biotage Flash 400M system was used to improve a pre-existing but inefficient process which used a stainless-steel self-packed column, and 26 x 1.5 kg injections in order to process a 40 kg batch

Parks EL, Awuah MD, K.-F

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