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As a result, T cells do not engage in this argininosuccinate synthetase 1-mediated synthesis of arginine

For instance, a meta-analysis demonstrated that Astragalus combined with RAS inhibitors markedly increased total efficacy rates while reducing urinary protein excretion rate (UPER), serum creatinine (Scr), and blood urea nitrogen (BUN) levels in stage III DN patients (Sun et al., 2022

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For instance, in cardiomyocytes, mitochondrial impairment may primarily disrupt energy production essential for cardiac contraction, while in neurons, it can lead to synaptic dysfunction and neurodegeneration [32]