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GLCM-based analysis is highly dependent on a given systems operator-dependent settings, such as time gain compensation, depth of focus, and post-processing digital/analog filters 68

When metabolic stress occurs, MOTS-c in cells can be transferred to the nucleus in an AMPK-dependent manner and bind to transcription factors regulated by ARE, thus improving the stress resistance of cells (16, 24)

This integrated approach may allow lower doses or shorter cycles of BPC-157 while still achieving desired healing outcomes

Figure 2: Changes in Body Weight (%) from Baseline to Week 72 in Study 2 in Patients with Obesity or Overweight and Type 2 Diabetes Note: Based on average percent weight change of each randomized patient within each specific treatment arm from 100 imputed datasets including observed data and imputed data using hybrid approach for missing values