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doi: 10.3760/cma.j.issn.0376-2491.2017.23.013 17 ChenM.DongQ

Most likely, the germination of the vtc2/vtc5 double mutant is made possible by the reduction of dehydroascorbic acid to AsA by means of dehydroascorbate (DHA) reductase (see below), since it has been demonstrated and repeatedly confirmed that mature orthodox seeds have no AsA (reduced form) and retain only a small amount of DHA (oxidized form) ( Overexpression of GGP mostly (but not always) increased AsA content in model and non-model plant species ( VTC2 in Arabidopsis ( 3.4 Regulators of the pathway Both overexpression studies and data on the effects of feeding with precursors ( de novo biosynthesis with a typical negative feedback mechanism, apparently affecting three enzymes in the pathway: PMI, GGP, and l-GalDH ( Arabidopsis phosphatase possibly activating the myo-inositol alternative branch (Zhang et al., 2008)

The overt phenotype of the mutant mice and blood counts were not significantly different from wildtype (Supplementary Fig

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