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Much of the supporting research summarized in peer-reviewed literature relies on animal studies, such as GLP-1 receptor-knockout mice and rodent injection trials, rather than large-scale human trials, and peptide-based drugs overall are described as rarely used in real-world patient care because of lingering questions about safety, effectiveness, and inadequate insurance coverage

See more Carbonic anhydrase inhibitors dorzolamide and brinzolamide, when administered topically in the eye, are not prohibited

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This is not the only approach, but it represents a conservative, well-structured entry point