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NAD + binding domains are located on top of the N and C-domains

Individual PD patients do not often show easily detectable grey matter loss at diagnosis, although at group level, PD patients show cortical thinning and reduced subcortical and cerebellar volume compared to controls 119,120

[32] However, in more complex situations, such as nerves being damaged by severe B12 deficiency, full recovery can sometimes take up to a year

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Keleku-Lukwete N., Suzuki M., Otsuki A., Tsuchida K., Katayama S., Hayashi M., Naganuma E., Moriguchi T., Tanabe O., Engel J.D., et al

But judging by the various responses on here, it doesn't seem to matter unduly, other than for pain of the needle actually going in