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It is clear how the respiratory system undergoing a chronic oxidative stress can release slowly, but steadily, a huge amount of already mentioned toxic compounds able to act locally and to enter the circulation and cause serious damage

HGF/c-Met signalingalso has a role in angiogenesis either by direct influence of c-Met activation in vascular endothelial cells, or by regulation of the expression levels of other angiogenic factors in tumor cells