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Inhibition of cyclooxygenase-2 (COX-2) with celecoxib significantly reduced PGE2, enhanced IFN- production and NO release, and increased phagocytosis of MTB by macrophages (97)

Pathogenic levels of Hcy affect inflammatory determinants such as adhesion molecules, endothelial dysfunction, oxidative stress, leukocyte adhesion, or reduced NO bioavailability [106]

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The combination of DHA with cisplatin triggered cell death in pancreatic ductal adenocarcinoma (PDAC) by promoting the degradation of GPX4, creation of ROS and the degradation of ferritin, leading to induction of ferroptosis (Du J