Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV (2015) Nephron organoids derived from human pluripotent stem cells model kidney development and injury
Representative research domains include: In vitro skin and connective tissue models examining fibroblast activity, ECM deposition, collagen organization, and responses to oxidative stress
Chen C, Li HC, Niu Y, Liu C, Lin ZJ, Cai J, Li WH, Ge WZ, Chen RJ, Kan HD (2019) Impact of short-term exposure to fine particulate matter air pollution on urinary metabolome: A randomized, double-blind, crossover trial
Lipid peroxidation mainly includes the reaction of ROS with lipid molecules in cell membranes, raising membrane fluidity and permeability, thereby having an impact on cell structure and function ( Moreover, DNA damage activates stress response mechanisms within cells, possibly causing apoptosis or mutation, further compromising the health of gingival tissues ( 2.3.3 Depletion of antioxidant systems During the prolonged progression of chronic periodontitis, oxidative stress persists, causing depletion and imbalance of antioxidant systems ( 3 Antioxidants and their roles 3.1 Types and functions of main antioxidants Antioxidants are compounds which is capable of neutralizing and clearing oxygen free radicals and other oxidants within cells, having a huge impact on the prevention and treatment of chronic inflammatory diseases
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