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The mean change of ALSFRS-R total score during the 12 months after baseline, in subjects treated with ALCAR 3 g/day and not treated subjects

Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial

PMID 18272931

In most cases, the bigger concern is reduced effectiveness, not toxicity

The prevalence of promiscuous equilibrative transporters of non-native substrates has significant implications for strain development in biotechnology and offers an explanation as to why transporter engineering has been a challenge in metabolic engineering