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Formononetin, an isoflavone compound derived from a variety of medicinal plants and herbs such as including Trifolium pratense and Astragalus membranaceus , has been identified as exhibiting anticancer potential against various cancer types, such as cervical, head and neck, colon, breast and ovarian cancers ( via the inhibition of Akt activity (Zhou et al., 2019), indicating its potential as a therapeutic agent for breast cancer inhibition

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Studies have reported the expression of enzymes involved in one-carbon metabolism in ovarian granulosa cells, suggesting their potential capacity for SAM production, methylation processes, and epigenetic modulation during follicular development [254]

Human samples were provided by the Network for Pancreatic Organ Donors with Diabetes (nPOD;RRID:SCR_014641), a collaborative type 1 diabetes research project sponsored by JDRF (nPOD:5-SRA-2018-557-Q-R) and The Leona M