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Despite these challenges, IN delivery is predominantly used for emergency medicine in clinical settings due to its rapid onset, ease of administration, and ability to bypass hepatic first-pass metabolism

Poor graft survival is mainly presented as an absorption rate of up to 80%, liquefaction necrosis, and fiber calcification, which ultimately lead to unsatisfactory or failed surgical results [1]

Melasma is one of the more commonly treated concerns, and many report improvement but because melasma is hormone- and UV-driven, results are best combined with sun protection and, where relevant, hormonal evaluation

The extremely high UV index in Brisbane means that even though treatments are effective, the use of a high SPF sunscreen is essential for maintenance

These natural medicines are mainly classified as: flavonoids, polyphenols, alkaloids, glycosides and terpenes