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Similar results were observed in a rat model of restraint stress, where WS in the form of a root preparation reduced the effects of stress on peripheral T-lymphocyte counts (CD3+, CD4+, and CD8 + populations), as well as IL-2, INF-, and polymorphonuclear leukocyte counts [172]

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The TGR inhibitor demonstrating greatest efficacy in treating infected mice, 2 , was also studied after oral administration: 2 (200 mg/kg p.o.) gave plasma concentrations of 0.71, 0.77, and 0.40 M at 30, 60, and 120 min, respectively (Supplementary Table 19)