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Indeed, the CRBN IMiD-binding site is a hydrophobic tritryptophan pocket

Patients should be encouraged to consume B12-rich foods, including: Meat, particularly liver and kidney Fish and shellfish Dairy products (milk, cheese, yoghurt) Eggs Fortified breakfast cereals and plant-based milk alternatives For patients following plant-based diets, fortified foods and supplementation become essential, as vitamin B12 is naturally found almost exclusively in animal products

Macrophages Macrophages are a heterogeneous population of multi-functional innate immune cells capable of phagocytosis

Among the voltage-gated channels, 40 are Kv channels, which are further classified into 12 subfamilies (Kv1-Kv12) and represent the largest group of channels (Khling and Wolfart, 2016)

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