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Chronic systemic diseases e.g

B 8 , 65176529 (2020)

These reactions may deactivate a compound, activate a medication or create a reactive intermediate requiring rapid conjugation

Oxidative stress and cerebral endotelial cells: regulation of the blood-brain-barrier and antioxidant based interventions

However, it is important to strike that although these data underscore the significance of GSH depletion for a short period of time (up to 24 hours), it is conceivable that depletion of GSH per se for serveral days may result in a different outcome