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Despite a common consensus on metabolic defects, specific features have been described in ALS fibroblasts depending on TDP-43 mutations

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Results indicate ALP exposure during adolescence potentiates the rewarding properties of MOR and induces persistent changes in ERK-signaling within the VTA-NAc pathway, a brain circuit highly implicated in the regulation of both drug reward and mood- related behaviors

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Fluorescence images were acquired using a Deltavision real-time microscope (Applied Precision), a thunder microscope (Leica) or an Apotome Weiss microscope with Deltavision imaging software, Thunder Leica image acquisition software or Apotome Zeiss Imaging software, respectively