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The FTBR nanoparticles, which incorporate a ROS-responsive linker, demonstrate responsiveness under elevated ROS conditions, facilitating therapeutic release at ROS-related pathological brain sites in AD mice following intranasal administration (Wang et al., 2024)

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Although I could only find rat studies on PubMed, the peptide has generated excellent results in a Phase 2b clinical trial run by Metabolic Pharmaceuticals: The drug codenamed AOD9604 was taken orally once daily by 300 obese patients at five trial sites over a 12-week period

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The Journal of clinical investigation , 53 (5), 12741283