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Similarly, a study by Andreas Linkermann and colleagues demonstrated that mice with Fsp1 deficiency or GPX4 dysfunction exhibit increased sensitivity of renal tubular epithelial cells to ferroptosis during AKI [26]

TGM, transglutaminase Graphical abstract Introduction Terminal differentiation of keratinocytes (KCs) in the epidermis produces a nearly impermeable barrier that separates the organism from its environment