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Even though we confirmed that astrocyte activation induces lactate release in the extracellular space, we cannot exclude that other mechanisms might be activated by optogenetic stimulation of astrocytes

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Furthermore, our own studies have shown that pharmacological targeting of NK-1R with the antagonist L703,606 can not only prevent the development of damaging inflammation due to streptococcal CNS infection when administered prophylactically, but can also reverse infection-associated gliosis and demyelination when delivered therapeutically without increasing CNS bacterial burden (Chauhan et al., 2011)

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303 , E1397E1407 (2012)

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