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In the study of cagrilintide versus liraglutide, 706 patients aged 18 years and older without diabetes and with a body mass index of at least 30 kg/m 2 or at least 27 kg/m 2 with hypertension or dyslipidemia were enrolled

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This non-peptide mechanism, elucidated through cryo-electron microscopy and published in the Proceedings of the National Academy of Sciences in 2020, overturned decades of pharmacological dogma that class B GPCRs could only be meaningfully activated by peptide ligands