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In MDD patients with MDD, there was a rise in Eggerthella and a decrease in Sutterella ( Methanobrevibactersmithii ) ( BDNF activities such as neural survival and CNS development ( Figure 4 The SCFAs also influence the secretion of intestinal hormones such as peptide tyrosine (PYY), cholecystokinin (CCK), and glucagon-like peptide-1 (GLP-1) from gut mucosal enteroendocrine cells that express free fatty id receptors (FFARs) ( Figure 5 ( Figure 5 The pathophysiology of various mental diseases, including anxiety and MDD, is linked to gut microbiota dysbiosis ( Hungatella and Fusicatenibacter showed favorable associations, with Butyricicoccus, Clostridium, Desulfovibrio piger, Parabacteroides merdae , and Hungatella showing positive correlations, with the depressive phenome

One study on the pain-modulating IceWave patches showed a meaningful reduction in the chronic inflammatory process (of COX-2, PGE-2, PGF-2, IL-1 and lactic acid) as well as changes to neuropeptides Substance P and Vasoactive Intestinal Peptides (VIP) [R]