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101 IORA (2017)

While the pain may start as a dull ache, it can quickly progress into sharp, persistent discomfort if not treated properly

It's usually sharp, burning, or feels like an electric shock rather than a dull ache

Healthcare providers should schedule follow-up within 2-4 weeks of starting tirzepatide to review glucose patterns, assess tolerability, and make necessary medication adjustments

In addition, the analgesic effect of melatonin is mediated through activation of supraspinal sites, inhibition of spinal nociception, and modulation of various neurobiological systems, including GABAergic, opioid, and glutamatergic systems [65]