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The kinase TAK1 ( Figure 2 ) specifically regulates the maturation and survival of single-positive (SP) thymocytes, rather than their selection ( Noteworthy, downstream of the IKK complex in the NF-kB signaling cascade, recent studies using CD4cre-inducible models of RelA and c-Rel deletion have shown that these NF-kB subunits are not necessary for thymic development ( NF-B signaling and T cell homeostasis Single positive T cells migrate to the periphery, where they can persist for months as naive T cells

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