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The subsequent reaction is catalyzed by FlcE, an Fe(II)-dependent enzyme that mediates oxidative decarboxylation and N-hydroxylation of the cysteinyl adduct (Patteson et al

In mice, SIRT3 inhibits the generation of ROS and alleviates oxidative stress and cardiac hypertrophy by activating the AMPK pathway (62)

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Metabolization of methionine to the methyl donor S-adenosylmethionine (SAM) has consequence for polyamine, carnitine, phospholipid, and creatine synthesis as well as epigenetic modifications such as DNA- and histone tail methylation