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Alternative TB-500 protocols for different goals Daily low-dose protocol For patients who prefer more frequent, lower-volume injections: Dose: 750 mcg 1 mg daily , subcutaneous Duration: 12 weeks continuous, then 4 weeks off Provides steady-state tissue levels without peaks and troughs of twice-weekly dosing Preferred by some patients with needle anxiety (smaller volume per injection) Body-weight-based TB-500 dosing Some practitioners calculate by weight for greater precision: Loading: 3060 mcg/kg per injection , twice weekly Maintenance: 30 mcg/kg once weekly For a 75 kg patient: loading = 2.254.5 mg per injection

The GLP-1 and GIP components improve insulin secretion and sensitivity, driving blood glucose down

High-quality human clinical trials are lacking

missed doses reduce effectiveness

The key contribution is practical: prospective evidence on feasibility, tolerability, and treatment continuity in a real-world, later-line gastric cancer population