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Many cases of idiopathic male infertility show elevated oxidative markers in semen, indicating that oxidative stress is a frequent, underrecognized cause

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The SCN receives light input directly from the retina and conveys time-of-day signals to peripheral clocks throughout the body, ensuring systemic synchronization ( At the molecular level, circadian rhythms are primarily driven by transcriptional-translational feedback loops (TTFLs) and rhythmic posttranslational modifications, such as phosphorylation and ubiquitination (Mendoza-Viveros et al., 2017)

The cumulative 5-year budget impact demonstrates savings of $14.2 million to the health care system